Liver cell dysplasia(LCD) is commonly associated with some liver diseases such as liver cirrhosis or hepatocellular carcinoma and has been regarded as a premaligant condition.
In order to clarify the question of whether or not LCD is a premalignant liver lesion, iron special staining, Prussian blue, was done.
The specimens were collected at the department of pathology, Chungnam National University College of Medicine from January 1983 to September 1992.
@ES The results were as follows:
@EN 1. Of observed 48 cases, 34 were hepatocellular carcinoma(70.8%), 11 were metastatic carcinoma(22.9%), and 3 were hepatoblastoma(6.3%).
2. LCD was present in 26 of 34 cases(76.5%) of hepatocellular carcinoma, of 11 cases(45.5%) of metastatic carcinoma, and 1 of 3 case(33.3%) of hepatoblastoma.
3. The carcinoma cells were free iron deposition(iron excluding foci) in contrast to the neighboring dysplastic nonneoplastic normal hepatocytes.
4. The presence of iron deposition in LCD cases was similar to or more severe than that of normal hepatocytes.
In summary, the results obtained from the present study indicate that LCD reflects neither a regenerating condition nor a premalignant lesion but suggests a reactive change or accompaning lession.
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